WHO is working to contain an outbreak of Marburg virus disease (MVD) that has appeared in eastern Uganda on the border with Kenya, the first case of which was detected by the Ministry of Health on 17 October, a 50-year-old woman who died at a health centre of fever, bleeding, vomiting and diarrhoea on 11 October. Laboratory testing at the Uganda Virus Research Institute (UVRI) confirmed the cause of death as MVD.

At least one person is confirmed to have died of MVD and several hundred people may have been exposed to the virus at health facilities and at traditional burial ceremonies in Kween District, a mountainous area 300 kilometres northeast of Kampala.

Marburg virus disease is a rare disease with a high mortality rate for which there is no specific treatment. This virus is among the most virulent pathogens known to infect humans. The incubation period is 2-21 days, and symptom onset is sudden and marked by fever, chills, headache, and myalgia. Although MVD is rare, it can result in large outbreaks with high case fatality rates (CFR range from 23 to 90%).

The Ministry of Health has sent a rapid response team to the area supported by staff from the World Health Organization, the Centers for Disease Control and Prevention (CDC) and the African Field Epidemiology Network (AFNET).

WHO is also providing medical supplies, guidance on safe and dignified burials, and has released USD 500 000 from its Contingency Fund for Emergencies to finance immediate response activities.

Ibrahima-Soce Fall, WHO Regional Emergency Director for the Africa region said, "We are working with health authorities to rapidly implement response measures. Uganda has previously managed Ebola and Marburg outbreaks but international support is urgently required to scale up the response as the overall risk of national and regional spread of this epidemic-prone disease is high."